Postdoctoral Fellow - Tumor Immunology

City of Hope

Duarte, CA

Job posting number: #7083484 (Ref:10012334)

Posted: August 20, 2021

Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary:

A Postdoctoral Fellow position is available in the laboratory of Dr. Heather McGee, MD, PhD, Assistant Professor in the Department of Radiation Oncology and Faculty Member in the Irell & Manella Graduate School at the Beckman Research Institute of City of Hope. Post-doctoral applicants should be highly motivated, creative, independent, fast learners, with a strong work ethic and critical-thinking abilities, who are seeking to perform high-impact research in an interdisciplinary lab and publish in high-impact journals.

Dr. McGee's laboratory seeks a post-doctoral researcher interested in tumor immunology and studying the immune response to radiation in multiple cancer types, including liver cancer (hepatocellular carcinoma), colorectal cancer, pancreatic cancer and lung cancer. Dr. McGee completed her Ph.D. in the laboratory of Dr. Richard Flavell at Yale University and developed an IL-22-IRES-sgBFP mouse model that can be used to visualize IL-22 in vivo in response to various inflammatory stimuli, including ischemia/reperfusion injury in the liver, inflammation-associated colorectal cancer, and IL-23-mediated skin inflammation/psoriasis. She worked with Dr. Flavell and others to discover a role for IL-22 in skin wound repair and identified that IL-22 acts on fibroblasts to increase the expression of fibronectin and collagen, while promoting the differentiation of fibroblasts to myofibroblasts. More recently, she worked with colleagues at UC Davis to characterize unique aspects of the peripheral immune after radiation to different organs, include a decrease in cytotoxic NK cells and an increase in TIM3+ NK cells. During her post-doctoral training at the Salk Institute, she has developed techniques to identify neoantigen-specific T cells in patients with NSCLC. Her lab at City of Hope is focused on studying the role of radiation-induced cell death mechanisms in the activation of innate lymphoid cells (ILCs) in various tumor microenvironments. The research spans the entire spectrum from cell culture to murine models (e.g. transgenic mouse models and knock-in reporter mice) to patient samples.

The long-term goals of the McGee lab are to identify key molecular and immunologic pathways that can be targeted to enhance the immune response to radiation and develop personalized medicine approaches for cancer patients treated with radiation. Her lab is dedicated to translational research and utilizes both cancer models and patient tissues to test novel insights from the clinic using a "bench-to-bedside" strategy.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in life or biomedical sciences, immunology or a related discipline is required. Candidates with an M.D. and significant research experience will be considered.
  • Proficiency in immunology, molecular and cellular biology, cancer biology and/or animal (mouse) studies is required.
  • A desire to work in a collaborative, interdisciplinary lab environment that values communication, initiative, professionalism, and teamwork is required.

Additional Information:
  • Dr. McGee's research is currently supported by an NIH R00 grant from the National Cancer Institute and a generous start-up package from City of Hope.
  • Research findings from Dr. McGee and colleagues have been published in Nature , Nature Communications , Clinical Cancer Research , Journal of Immunology , Journal for Immunotherapy of Cancer , International Journal of Radiation Oncology* Biology* and Physics , and numerous other journals.
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.



  • Posting Date: Aug 19, 2021
  • Job Field: Clinical Research
  • Employee Status: Regular
  • Shift: Day Job

City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.

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