Assistant Research Professor - Precision Oncology of Gastrointestinal Cancers

City of Hope

Monrovia, CA

Job posting number: #7084148 (Ref:10013119)

Posted: May 4, 2022

Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution.  AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities.  Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding.  We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

An Assistant Research Professor (ARP) position is available in Beckman Research Institute of City of Hope.  The Assistant Research Professor series is a faculty position designed for research professionals with a solid track record of research achievements in the field of translational oncology, preferably gastrointestinal (Gi) oncology. The candidate in this role is expected to have relevant research experience, a productive track record of first or senior author publications in high impact journals and mentoring experience for post-doctoral fellows and other staff in a research laboratory. The primary function of an ARP will be to support the research infrastructure and activities of the institution by utilizing the specialized research skills, knowledge and experience to research programs or institutional core laboratories.  Individuals appointed as ARP will receive a one-year fixed-term contract.

This candidate will become a part of the multidisciplinary research team headed by Dr. Ajay Goel, Professor and Chair, Department of Molecular Diagnostics and Experimental Therapeutics. Our research group comprises of basic biologists, gastroenterologists, surgeons, medical oncologists and bioinformaticians, undertaking a number of collaborative projects involving large international consortia. Our research is focused on translational research as it relates to genomic and epigenomic characterization of various gastrointestinal cancers (GI) including colorectal, pancreatic and gastric cancers, and some of the key research topics include:

  • Development of circulating DNA/RNA-based liquid biopsy biomarkers for cancer diagnosis, prognosis and predictive response to various therapies.
  • Study the epigenetic basis of GI cancers (e.g. aberrant DNA methylation, histone modifications and non-coding RNAs.
  • The genetic basis of early-onset and familial/hereditary colorectal cancers. 
  • The role of tumor microenvironment, stem cells, immune regulation and identification of novel targeted therapies. 
  • The role of extracellular vesicles/exosomes as in cancer pathogenesis and their role as disease biomarkers. Our group performs cutting-edge research in GI oncology, is very productive and publishes in high-impact journals such as Gastroenterology, Cancer Cell, PNAS, JNCI, Clinical Cancer Research, Nature Communications, Nature Reviews Gastroenterology and Hepatology, Annals of Surgery etc.

Key Responsibilities include:

  • Devise, plan, document and advance basic science and translational projects in the relevant research area.
  • Generate data for grant applications and prepare manuscripts for publication.
  • Work in close collaboration with the PI and other team members and external collaborators, including presentation of progress internally or externally.
  • Train and supervise multiple post-doctoral fellows and technical staff.

Basic education, experience and skills required for consideration:

  • PhD and/or MD/PhD
  • Evidence of first or senior author peer-reviewed publications
  • Prior molecular, cancer biology and/or translational research experience and evidence of project development
  • Prior evidence for any obtaining any grant funding and plans for seeking extramural grant funding within 1-3 years of joining.

Additional Information:  

  • You will have the unique possibility to drive research towards a novel cancer diagnostics and therapeutics at the interface of science and translation to the clinic and publish high-impact journals. City of Hope offers a competitive salary, along with institutional medical insurance and other benefits, including generous institution sponsored retirement benefits for this position.
  • Please submit your current CV/resume along with a cover letter highlighting your research accomplishments, a brief statement explaining how your past research ties in with the goals of our laboratory, and future career plans.
  • For more information about the groundbreaking research taking place in the Ajay Goel, Ph.D lab, please visit www.cityofhope.org/mdet.
  • As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer.  All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.


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